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T0 lung cancer is an intrathoracic tumor with an unknown primary site that is diagnosed as originating from lung tissue by histological examination. A 52-year-old man presented with esophageal stenosis. Esophagogastroscopy revealed severe stenosis of the upper esophagus with normal mucosa. Chest computed tomography showed a mass adjacent to the azygos vein and right main bronchus, and another mass...
Background In Japan, there have been few recent reports of large-scale studies on the characteristics and optimal treatment of esophageal foreign bodies. Methods We analyzed data on 90 patients diagnosed as having esophageal foreign bodies treated between April 2002 and August 2007. Results In children younger than 15 years (n = 13), the types of foreign bodies included coins (n = 9), food (n...
Although recent studies have shown that early enteral nutrition (EEN) has certain advantages over parenteral nutrition for preventing postoperative complications, few previous studies have examined the effects of enteral nutrition in patients undergoing esophagectomy. Here we review the effects of EEN with regular polymeric or other disease-specific enteral formulas in patients undergoing esophagectomy...
Endoscopic submucosal dissection (ESD) has gradually gained acceptance as one of the standard treatments for esophageal squamous cell carcinoma in Japan. Principal indications are little likelihood of nodal metastasis and having technical resectability. All lesions with preoperative diagnosis of high-grade intraepithelial neoplasms, including carcinomas in situ (T1a-EP), carcinomas invading the lamina...
Background No standard procedure exists in respiratory management, including mechanical ventilation, which is commonly administered, after thoracic esophagectomy for esophageal cancer. Methods Various perioperative clinical parameters and complications were retrospectively compared between the patients who underwent mechanical ventilation (MV group, n = 38) and those who were extubated immediately...
Esophageal carcinosarcoma is an extremely rare tumor, and surgery is the mainstay of treatment. We report two patients with carcinosarcoma of the esophagus who received neoadjuvant chemoradiotherapy and underwent curative resection. Patient 1 was a 50-year-old man with a type 2 lesion in the upper thoracic esophagus; clinical stage was T3 or partial T4N1M0. After chemoradiotherapy the tumor and the...
We reviewed the clinicopathological characteristics of 14 patients who underwent resection of basaloid squamous carcinoma (BSC) of the esophagus. The mean age was 65.3 years, and all patients were male. Seven patients had superficial BSCs and 7 had advanced BSCs. BSCs were associated with high rates of lymph node metastases and venous invasion. With regard to immunohistochemistry, the rate of cyclin...
A male patient in his thirties was referred with dysphagia lasting 8 years. He had a history of a laparotomy for a testicular tumor in his twenties. From an upper gastrointestinal contrast X-ray, he was diagnosed to have sigmoid-type achalasia (greatest transverse diameter, 80 mm). Hand-assisted laparoscopic Heller-Dor surgery was performed because straightening of the esophagus using only a laparoscope...
In contrast to Western countries, in Japan esophageal adenocarcinoma and classic Barrett’s esophagus (long-segment Barrett’s esophagus) have been considered extremely uncommon. Although alternative therapeutic techniques such as endoscopic ablation, photodynamic therapy, and endoscopic mucosal resection have been improved, esophagectomy remains the gold standard treatment for high-grade dysplasia...
Aim Primary esophageal small cell carcinoma is a comparatively rare disease. It is thought to have a poor prognosis, and no standard treatment strategy has yet been established. Surgical cases of small cell carcinoma of the thoracic esophagus were reviewed with regard to clinical characteristics and treatment strategy. Patients and methods Among the 993 patients who underwent an esophagectomy for...
Background The prognosis of esophageal cancer patients is poor. Cisplatin (CDDP) is most often used for advanced esophageal cancer; however, the emergence of drug resistance has prevented successful treatment in many cases. Methods Using microarray analysis, we identified GP73 as a candidate gene that is overexpressed in TE4, an esophageal cancer cell line which is highly resistant to CDDP. We downregulated...
In an attempt to improve survival of patients with locally advanced esophageal cancer, chemoradiotherapy consisting of cisplatin, 5-fluorouracil (5-FU), and irradiation has recently been used. For such patients, concurrent chemoradiotherapy using docetaxel in combination with cisplatin and 5-FU has been introduced and is under evaluation. We herein report an esophageal cancer patient with concomitant...
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